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KMID : 0043320100330020293
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Archives of Pharmacal Research
2010 Volume.33 No. 2 p.293 ~ p.299
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Identification and Assessment of Permeability Enhancing Vehicles for Transdermal Delivery of Glucosamine Hydrochloride
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Choi Young-Wook
Han In-Hee
Choi Sung-Up
Nam Dae-Young
Park Young-Mi
Kang Myung-Joo
Kang Kyoung-Hoon
Kim Yong-Min
Bae Gun-Ho
Oh Il-Young
Park Jong-Hyeok
Ye Jin-Soo
Choi Yoon-Bae
Kim Duk-Ki
Lee Jae-Hwi
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Abstract
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As an initial step to develop the transdermal delivery system of glucosamine hydrochloride (GL-HCl), the permeation study across the rat skin in vitro was performed to identify the most efficient vehicle with regard to the ability to deliver GL-HCl transdermally. The GL-HCl formulations such as o/w cream, liposome suspension, liposomal gel, and liquid crystalline vehicles were prepared and compared for transdermal flux of GL-HCl. The liquid crystalline vehicles were more effective in increasing the skin permeation of GL-HCl than o/w cream and liposomal vehicles. Of the liquid crystalline vehicles tested, the permeation enhancing ability of the cubic phase was greater than that of the hexagonal phase when the nanoparticle dispersion was used. The skin permeation enhancing ability of the cubic nanoparticles for GL-HCl was further increased by employing both oleic acid and polyethylene glycol 200. Therefore, the cubic liquid crystalline nanodispersion containing oleic acid and PEG 200 can provide a possibility of clinical application of transdermal GL-HCl.
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KEYWORD
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Glucosamine hydrochloride, Cubic nanoparticle dispersion, Hexagonal nanoparticle dispersion, Cubic bulk phase, Hexagonal bulk phase, Transdermal delivery, Liquid crystalline phases
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